Cox-II Inhibitors – Why They Appear to Work and Why They Can be Fatal

Remember an earlier time when folk remedies and Model-T cars were plentiful. There were few pain relievers available. The few lucky individuals got a drink of whiskey to numb the pain. Aspirin (salicylic acid) was then interested. Everyone thought things were great. People finally had a medicine that masked pain to minimize joint pain. For a short amount of time, this relief worked very well. Reports started coming in about stomach bleeding, blood thinning, gastrointestinal damage, kidney problems and an entire host of many other problems. This is because of the "shotgun" way NSAIDS operate. Now research has taught us better. A review article that was published in the New England Journal of Medicine, showed that anti-inflammatory drugs including both prescription and over-the-counter such as NSAIDS and COX-2, including Advil, Motrin, Aspirin, Aleve and more than 20 others have caused more than 16,500 deaths and about 103,000 individuals to become hospitalized each year in the United States alone. That has to make you wonder what could happen to you each time you swallow one of those little pills.

Why can NSAIDS be Fatal?

Studies have shown several reasons for fatalities caused by NSAIDS. Starting with the earliest generation NSAIDS, non steroidal anti-inflammatory drugs, seemed to work a little on both COX-1 and COX-2. Both pathways regulate inflammation in one way or another. The NSAIDS target the reserve of COX-1, the enzyme cyclooxygenase, and tends to severely ignore COX-2. This means that the medicine works to cover the pain, but have side effects due to the fact that COX-1 controls functions of the kidney, stomach, and the platelets. The COX-1 enzyme blocked is present in many parts of our body, which is why patients have unplanned side effects, such as stomach bleeding and ulcers, along with many other effects that may lead to extremely serious conditions for example, heart attacks or strokes - or even death. With NSAIDS, patients are offsetting several of their body systems simultaneously instead of targeting the particular body system that is responsible for the inflammation. COX-1 is more of a shotgun approach, where COX-2 tends to be more the targeted attack. The problem occurs when patients initiate the target attack and the natural response of the body.

"Enhanced" COX-2 Drugs Were Introduced

Developing COX-2 drugs became a huge breakthrough throughout the pharmaceutical industry. The ability now existed to patent the product and even market new drugs like Vioxx or Celebrex. Joint pain drugs soon became what producers thought to be the best drug sellers that ever existed. The theory was to target effects of the COX-2 inhibition and solve the problems associated with NSAIDS. There would be the benefits that COX-1 offered without a single side effect. The only downside was that they are extremely expensive. The average patient could easily spend $200 or more each month. When comparing this to only $30 for effective therapies like glucosamine, this is a much cheaper product with no side effects. Doctors will not tell you is that other side effects of COX-2 are blood clots or stroke, a risk of sudden heart attack, both of these without having preexisting heart disease. Otherwise healthy individuals could have severe health problems simply by using COX-2. These COX drugs seem to work great at relieving the pain, but they kill many people often. Now, doctors are becoming smarter and are more aware of the lethal side effects these drugs have and most have completely stopped prescribing them to patients. The less educated doctors hear what the drug representatives tell them and prescribe a product for specific conditions. Luckily, many of our doctors are finally waking up and realizing what COX-2 inhibitors cause in many of their own patients.

The System of Unbalanced Checks and Balances!

The body contains thousands of checks and balances systems that are designed to prevent both extremes and unbalances. Think of the number of systems that are working within you currently to help maintain optimal levels of glucose, oxygen, water and many other chemicals each and every second. A COX-2 pathway functions in a very similar way. When a patient inhibits COX-2 enzymes, they simply mask the inflammation and pain, which bypasses the side effects caused by COX-1. So far, so good, right? The downside is that COX-2 is much like COX-1. COX-2 also slows BLOOD CLOTTING. This is the instance that COX-2 becomes fatal. When an individual gets cut or experiences minor trauma, they sever blood vessels. This simple bleeding can’t continue or the individual would bleed to death. Within seconds the body releases clotting agents that help to bind blood and causes the formation of a clot. This clotting agent alone stops the original blood flow while plugging the cut. In 2-3 minutes, the body can start the process that stops the blood from clotting. These processes begin at the same time, but the as soon as the first finishes; the second process starts within seconds and takes about 2-3 minutes to finish. The second process is called the rate limiting process. COX-2 causes a disruption in the second process which allows clotting to continue, more than it should. Anyone can imagine the fatal accidents that could result form clotting inside the body. You could have a clot in your heart and it could cause you to have a deadly heart attack. One clot in the brain could cause an individual to have a stroke. Luckily, new technologies have been found and new drugs are being developed, but these drugs cannot be marketed yet. Enter glucosamine.

The Facts about Glucosamine

Glucosamine works in a completely new way, and it is not at all related to either COX-1 or COX-2. Glucosamine works on a very basic level. It is so basic that the body already makes glucosamine in a small scale. Due to this reason alone, glucosamine can’t be patented (neither can testosterone)! One only problem occurs, as the body begins to age its ability to make glucosamine begins to fade as many years hard work starts to rise above the body’s natural ability to heal itself. Cartilage begins to break down, the development of bone spurs occurs, and joints can’t absorb the every day shocks. If left abandoned, this will lead to requiring joint replacements, excruciating pain, and immobility. Simply by using Flexicose, a very high quality liquid glucosamine supplement, an individual will reduce discomfort, soreness and even promote healthy cartilage in their body. Flexicose has a unique formula made up of glucosamine, MSM, chondroitin, and ten synergistic ingredients that offer you the most effective glucosamine product currently on the market.

Promoting Healthy Cartilage - Naturally

The major building block of your healthy cartilage is Glucosamine. Flexicose supplies the body with the glucosamine it requires to do its job and keep your body healthy when stiff joints prevents normal movement. Decades of wear and tear can’t be erased overnight. Flexicose usually takes about 2 – 3 weeks become fully effective. Do not easily become discouraged because your results may not be immediate. Stay on track and take the recommended dosage of Flexicose for one month in order to see the full advantage. If you need to, continue taking limited dosage of NSAIDS, and soon you will see that you will be able to only to take Flexicose for you joint pain. Remember, Flexicose is not covering joint discomfort, it allows you to get deep in the problem and repair what time has caused. Flexicose works so well and has none of the side effects of the deadly COX-1 and COX-2 drugs, which is the most important fact of all.

List of Ingredients in Flexicose

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